Dry Blood Spot Screening

Congratulations! This Entry has been selected as a semifinalist.

Dry Blood Spot Screening: One drop to help two lives

SpainBrazil
Year Founded:
2008
Project Stage:
Scaling
Budget: 
$100,000 - $250,000
Project Summary
Elevator Pitch

Concise Summary: Help us pitch this solution! Provide an explanation within 3-4 short sentences.

Facilitates early blood diagnosis of infectious and non-communicable diseases affordable for disadvantaged communities.

Compassionate world: One blood drop to help two lives, where social interaction and social motivation goes hand by hand.

Democratization of prevention.

WHAT IF - Inspiration: Write one sentence that describes a way that your project dares to ask, "WHAT IF?"

What if preventable diseases were really worldwide preventable?
About Project

Problem: What problem is this project trying to address?

Every year about 56 million die around the world. 35 million of these are due to non-communicable diseases and half of the non-communicable deaths occur from cardiovascular or heart diseases. When looking at it in more detail, you find that an astonishing amount of deaths are from treatable diseases. 7.1 million are related to high blood pressure, 4.4 million to high levels of cholesterol and 2.6 million deaths occur due to obesity. Followed by 1 million of people´s death being related to diabetes! When looking at the infectious diseases, you also identify the field mother-to-child transmission: Globally, it is estimated that more than 1 thousand babies are born with HIV everyday. AND MOST OF THIS COULD BE PREVENTED!

Solution: What is the proposed solution? Please be specific!

"Prevention is by far the best option. We need to focus on population-wide measures that make it easier for people to adopt healthy lifestyles. To do so, we need to engage other sectors in a whole-of-government approach. To do so, we have to be prepared to meet some powerful opposition from some powerful lobbies. But it can be done." -Dr. Margaret Chan 24/Feb/2010, OMS/WHO General Manager. Almost all new cutting-edge blood technologies related to health sector limits their impact radio due an old and difficult problem: Cold-chain. Logistics: Refrigeration is a must. Without it, blood coagulates and it spoils. We have identified 3 main barriers that explain why massive blood screening are not applied in regular basis, despite the benefits: (1) cold chain, (2) syringe and its needle, (3) cost. Another important barrier is the technical path in the lab. • Imagine a solution where no needles and syringes are required. Just a lancet for a painless finger prick is required. • Imagine a solution where no cold chain is required. Just a piece of paper and a post-man. • Imagine a solution that just needs a handled cutter and biochemistry, EIA, m-RNA or genetics reads-outs are possible. • Imagine that we collected so important amount of data that we could modify government’s policies where all citizens keeps healthy because they follow easy healthy behaviors.

Awards

2010: Biotechnology TECNOS Prize Award; 2011: Best Health Tech Innovation Galien Foundation Award, Ashoka Fellowship; 2012: Call to Innovation Challenge Winner (US), Gifted Citizen Award (Mexico) and 3 more...
Impact: How does it Work

Example: Walk us through a specific example(s) of how this solution makes a difference; include its primary activities.

September 11th 2014. Boehringer Ingelheim. Ingelheim, Germany February 23rd, 2014, Boehringer Ingelheim. Manila, Philippines May 5th. 2015 Boehringer Ingelheim. Sao Paulo, Brazil Henrik together with 318 Boehringer Ingelheim friends & co-workers in Ingelheim Cheryl together with 59 Boehringer Ingelheim friends & co-workers in Manila Adrian together with 294 Boehringer Ingelheim friends & co-workers in Sao Paulo Took part in our campaigns One drop to help two lives. They gave us One drop - first life! Right now all of them know their cardiovascular and renal risks. Thanks to their participation, 2.500, 55 and 276 community members received free blood analysis. (Second drop - Second life!). Thanks to that, for instance, Honeylyn from Manila knew that her kidney was not working properly and that she could start the treatment much earlier. Earlier in a healthier world means more quality of life. We measured, qualitative, the effect of our campaigns, through a Survey Monkey. Henrik, Cheryl and Adrian and their co-workers reinforce our initial thoughts: What do you think that the company you work for, offers you the option to participate in a campaign that helps you know which is your health status? 100% answered YES and over 97% would like to repeat the experience in the future. And the most important feed-back: over 86% of them had the chance to explain their participation in the initiative and what Making more Health is doing around the world to people from outside the company. (Family, friends and customers). This important fact pushes us to define a Co-Creating a Healthier World together with BI employees. (See Co-Creation point hereunder).

Impact: What is the impact of the work to date? Also describe the projected future impact for the coming years.

Just like we did in Boehringer Ingelheim, we have done different campaigns in Schools, Universities and Governments, 7 countries, 3 continents. Our solution can be extended and adapted through cultures, gender and age. We measure our impact quantitatively. We clearly differentiate between those who took actively part on the campaigns (blood analysis), with those who were aware about our campaigns (in-place healthy habits promotion) and those who beneficiate for a second free analysis. • Direct: over 5 k + 84 k pre-natal in Rio Janeiro (Brazil) (Instituto Vital Brazil) + 10 k pre-natal in Alta Verapaz (Guatemala)(Tu la Salud). • Indirect: over 35 k • Beneficiaries: over 5 k Also we measure our impact qualitatively with Survey Monkey follow-ups, as mentioned in IMPACT: How does it work

Spread Strategies: Moving forward, what are the main strategies for scaling impact?

The concept One drop to help two lives will become a standard tool that will change the way we treat diseases. We understand prevention is not about treating disease. It is about managing Health. And standing still is not an option. U.N adopts new Global goals, charting Sustainable Development for people and planet by 2030 (total 17 goals), number #3 strength in the need to track impact on health: Ensure healthy lives and promote well-being at all ages. DBS Screening can facilitate to accomplish that goal. DBS Screening could provide and facilitate important amounts of data that should help trace the right accomplishment of that goal. DBS Screening aims to move forward creating lab-sites in different areas. We know that we need to be global & local, and we must replicate the solutions and approaches that are working successfully in another areas. Investing in the patient experience is also fundamental to DBS Screening’s view of quality.
Sustainability

Financial Sustainability Plan: What is this solution’s plan to ensure financial sustainability?

Our business model is based on High Volume. We followed Aravind’s business model: High Volume, High Quality and Affordable cost. We are already profitable. We are financially profitable in developed countries (One drop – First life) and we are financially non-lost in developing countries (second drop – Second life). We work under campaign basis. It is time consuming and non-efficient but as a lean process it helps us understand the different players and how to increase participation so we don’t leave anyone aside. That is our DNA. To accelerate our impact we launched a program: Join us & Get involved (Sponsor a campaign for a healthier world). DBS Screening GOLD (25.000 Euros) 5.000 people will know their health status. DBS Screening SILVER (10.000 Euros) 2.000 people will know their health status. DBS Screening BRONZE (5.000 Euros) 1.000 people will know their health status. Revenues also will come from site-labs. We have a quite ambitious plan to replicate our lab worldwide, bringing blood diagnosis to villagers too poor to seek out health services. Revenues also will come from more added value tests, such as m-RNA or genetic tests, based on Dry Blood Spot Technology.

Marketplace: Who else is addressing the problem outlined here? How does the proposed project differ from these approaches?

We are focused on prevention of healthy people. This is already a different approach in comparison with regular blood analysis centers. Our focus is on human welfare. Our project differs from other approaches with our mission: democratization of prevention. With our proposal One drop to help two lives we create a cross subsidization model. This is quite new, due to the fact that DBS Screening takes care of you, and you take care of another person. We know that it works, because we have seen it. We have seen it in the eyes of the participants. Kids in schools, grandparents in a public event in their city-hall or employees that for a while leave their daily routine to play a new role as a facilitator of wealth and love. Compassion through one drop of blood is a new concept. You control your health and facilitate it to community members, who otherwise would have the risk to be out of any health system. Another difference is the experience itself. Participants (Students, employees and citizens) said that they were inspired by our initiative.
Team

Founding Story

I am passionate with the importance of early diagnosis and prevention. During my Military service I had the opportunity to be in touch with patients and families whose future plans were sadly broken due to a preventable disease. 9 years after that awakening experience, I realized how difficult it was to collect blood from healthy people when I took my son to take a standard vaccine. I still remember his crying. Believe me, as a father, it hurts. At that time I understood that we need to change the way we approach healthy people for health prevention awareness. It is from this person-centered approach that DBS Screening was born. Since then my life can be defined with just 3 words: Collect, Test and Prevent.

Team

Our solution is based on volunteers. We need to create a new bottom up approach, where peers interact with peers. This is the real win-win change-maker solution. Real change can just come from the bottom upwards. You put aside your fears if your best friend gives his/her hand to cross the Chasm to healthier behaviors. It is time to act and be part of the solution. We promote that you, as an individual, can host a campaign with our support and expertise. If you are a Company, University, NGO or a Government Agency and you want to provide a cost-efficient preventive action for your personnel, your clients, your students or your citizens, we are ready. It is fundamental rule that every campaign, even our very smallest one, is done with the active leadership from within the community. Anthony Robbins said: Motion creates Emotion, and then I add Let us move and Act.
CO-CREATION IDEA: Please offer a brief description of how you imagine a win-win partnership with Boehringer Ingelheim to better serve unmet needs in health. (Hint: Please mention the underlying business model envisioned that would make such a partnership sustainable.)

For us, to imagine a win-win partnership with BI to better serve unmet needs in health is challenging, and we don’t want to lose this opportunity because we don’t have time to lose.

Our “grand-challenge” Co-creation idea is: 1 Million x 1 Year. It is rather ambitious, but through active leadership from within all BI sites and BI employees we would like to impact 1 Million people in 1 year. We know that it could work, because we asked it. 97% of BI employees (Survey Monkey) would like to participate and 86% are eager to do it outside their comfort zone.

The objective is to empower BI community as motivated and supported health workforce. It is just MMH philosophy. 1 Million x 1 year’s objective seeks to spread awareness though our beloved people. School or University where our kids are studying. Our village where all our friends are living. Neighborhood business with great impact. Civil society, academia and community base organizations are key stakeholders in this process.

NEEDS: Based on you response above, please specify which of the following resources, operations or expertise by Boehringer Ingelheim you imagine leveraging to actualize the proposed co-creation opportunity. Please check all that apply. (Hint: while financing is often critical to scale, we are also interested in understanding what other assets or expertise could be leveraged).

Distribution Channels, Relationships/New Contacts, Human Resources.

EXPLANATION OF NEEDS: Please explain your choices in more detail.

It is a global project that involves all BI sites. We will need that BI opens its doors and facilitate transport to support local initiative when it will be required. We should start with MMH working group, leaded by Manuela Pastore and Philipp Baum. We need as well that BI helps us in define scientific outputs. We can collect a huge amount of data. Gender, Age, location, height, weight, smoker, pressure blood, IMC and 3-4 biochemistry parameters… Product management and scientific staff should define the scope of the project and how to sell our findings to scientific societies.

OFFER: What are the main assets you may contribute in a co-creation partnership with Boehringer Ingelheim that would better serve unmet needs in health?

Deep understanding of an unmet need in a specific market/context, Insights into pricing and financing of health products/services.

FOCUS AREAS: Which of the following best describes the main focus of your project? (select all that apply)

Improving the affordability of healthcare (e.g., microinsurance, reducing the economic cost of care), Remote care solutions for health management, treatment, and diagnosis, Packaging of health products and services to address needs currently unmet.

SECONDARY ENTRY FORM
Please share what your organisation and Boehringer Ingelheim will Co-Create together

We will create a healthier and a compassionate world, increasing awareness and stopping worldwide Silent Killer diseases’ exponential growth. We will do it thanks to an easy, painless and economic blood analysis, together with a peer-to-peer economic model ¨One drop to help two lives¨
We will facilitate early blood diagnosis of non-communicable diseases affordable for disadvantaged communities.
We think big: 1 Million Tests in 1 year worldwide.
We propose to diagnose Hb1Ac, Cholesterol and Creatinine to 1 Million people. (Diabetes mellitus / cardiovascular disease / Chronic Kidney Disease). Plus Pressure blood (Hypertension) and BMI (Body Mass Index). Pancreas, Heart, Kidney!

Please specify what your Co-Creation will result in:

a new service, a new distribution channel, a new market/customer group.

If you selected "other" above, please explain:
Please provide a 1-2 sentence summary of your Co-Creation idea

In high-income countries, people with Diabetes have full access to the care required to lead healthy and productive lives. (Take away: 1 out of 4 have diabetes or are overweight, and 50% don´t know it yet) By contrast, in low-resources countries, insulin and other essential aspects of care may be unaffordable or even unavailable. Unable to control their blood glucose, they develop serious complications early in life. And it is not fair at all.
But a single drop of blood can make the difference.
Diabetes, Cardiovascular, Hypertension, Obesity, Creatinine are interconnected and with our Co-Creation idea. We can do it Democratic.

How does this project link to the core mission of your organisation?

Our mantra is High Volume – High Quality and Affordable cost without leaving anyone aside.
This Co-creation opportunity is a unique opportunity. And we are ready.
We live in a world where, thanks to many companies like BI, we have the resources to beat virtually almost all diseases. How is it possible that Diabetes from 2004 to 2030 will decrease from position 19 to 10 (WHO Diseases or injuries ranking)?
Prevention is the solution. We know it because we have seen it.
We have seen again and again the non-realization of preventive campaigns. Campaigns that could have prevented much pain, suffering and save large amount of financial resources to all health authorities around the world.

Beyond social impact, how does this project link to Boehringer Ingelheim’s core business?

Our proposed Co-creation adventure 1 million 1 year, will ¨Lead and learn¨ doing good and doing well; that is BI’s core vision and area focus.
1 million 1 year will focus on Diabetes, Cardiovascular and CKD that is (2/3) main BI’s business lines.
Our former experience with BI employees in Sant Cugat (2011), Ingelheim (2014), Manila and Sao Paulo (2015) guarantees that our Co-Creation idea is 100% in line with looking forward to the future with confidence, engendering pride and emotions in employees and engaging beneficially for society. (We kindly ask to perform an internal BI survey)

What are the specific inputs and actions that each side will contribute to this Co-Creation idea based on each of your unique competencies and experiences?

○ My organization will contribute: We started small and we are still too small. Thanks to Making More Health, we got some notoriety in media.
However, without any doubt this Co-creation proposal 1 million 1 year is the project of our lives!
Our technology facilitates scale up. Since the beginning, we were thinking in scaling-up and replication.
Our experience curve allows us to replicate our lab in different areas worldwide based on a franchise model. Although transport cost is not an issue (cold chain is not required), we highly recommend placing labs strategically in areas with higher need. Global – Local approach.
Creativity, sustainability, innovation, compassion, positive impact, flexibility,

○ Boehringer Ingelheim will contribute: We will explain it in more detail in partnership expectations.
With more than 47.000 employees and present in 50 different countries, BI expertise is key to define and execute the Co-creation project.
We imagine BI contribution in two steps: (i) BI Headquarters where we should co-define target, scope and worldwide implementation of the project. We look for expertise in Global Health and (ii) BI local teams who should co-lead country call to action activities.
We need BI’s volunteers. We need to find out local BI’s intrapreneurs as Change Makers.

Please describe the potential revenue model for this Co-Creation idea.

Our initial business model is based on a Freemium Business model to enable FREE blood diagnosis for the poor.
In developing countries with limited resources government alone cannot meet health needs of all the poor and the challenges are to make the service affordable and with high quality.
Our solution provides blood diagnostics to the rich and poor alike, being self-supporting.
We find out that price is a participation barrier. We actively will promote to the same healthy citizen to take part in One Drop to help two lives initiative, where we will ask them to co-finance a free blood analysis to a person who can’t afford it.

What possible risks or challenges do you foresee?

1 million 1 year is a challenging Co-creation project.
In my research done together with BI employees in these last 2 weeks, several questions have arised, such as: (i) data confidentiality management, (ii) sample traceability, (iii) blood collection optimization, (iv) regulatory bodies, (v) biochemistry parameters to be tested, (vi) target population to be focussed on either schools, universities, health insurance, public health.
(vii) Compassion health care project to cross subsidisation One drop to help Two lives.

Is there anything else you would like to share about your Co-Creation idea?

Co-creating with BI and other players will facilitate reaching High Volume and keep our cost below 1 USD. It allows us to maximize service & impact rather than maximizing profit.
We believe that our Co-creation package can be easily franchised.
We do not have time to lose. Following International Diabetes Federation (IDF) from 2014 to 2035; Burden of diabetes will increase with more than 205 M people worldwide. People that today are healthy can keep themselves healthy with one single drop of blood.
We have ¨crazy¨ ideas. One drop to help Two Lives can align enemies. There is nothing more meaningful than the fact that one drop of blood here can save a live there.

How much input do you hope to receive from Boehringer Ingelheim?

I’d like to implement together, I mostly need strategic advice, I only need financial support, other (Please explain below).

If you selected "other" above, please explain:

I’d like to design together.

Besides Boehringer Ingelheim, what other types of partners might be valuable to carrying out your Co-Creation idea, and why?

Since we were notified that we were semi-finalist, we contacted several potential partners.
Positive answers.
We spoke with International Diabetes Federation and World Diabetes Foundation. A visit was planned but it was cancelled due dramatic terrorist events in Paris.
We spoke with Toyobo Co,. Ltd. manufacturer of immunodiagnostics and reagents for clinical chemistries worldwide. They hold the Hb1Ac patent and they already agree to provide reagents to our project at cost.
We spoke with htl-strefa world-leading medical device company that develops, manufactures and sells safety lancets.
We met Bio Pharma Logistics to explore how they can help us with sample delivery logistics worldwide.
We met Cellab, they offer a laboratory space for our European activities.

Comments

Ogo Maduewesi's picture

A big Congratulations as one of the Early Entry Prize Winners!
Awesome project there, wishing you best.

waleed shawky's picture

congratulations for the prize

Raja Shaleem Samuel Gill's picture

I very big congratulation. Good job Keep it up.