Explain what the "innovation" is about, e.g., is it the idea and/or the model you use to accomplish the idea, or your understanding of the target population, etc.?
The project is devoted to detect the immune response to vaccination based on the global and local vaccination programmes ongoing and to be established as well as its impact on the public health and on the public concerns on the safety. The innovation is based on current scientific knowledge as starting point to extend the state of the art in order to obtain a disruptive technology able to cover a current need in developed countries (HPV vaccination, cancer vaccines or influenza) but also opening opportunities for developing countries vaccination programs such as malaria, measles, etc... and/or quick actions to response a vaccine preventable diseases breakouts. The BEAM platform consists of two parts: plastic-based disposable biosensor and a portable reader. The main features are 1) to provide real-time individualized profile of the immune response to a vaccine or an infection, 2) affordability 3)feasible for industrial scale-up. It’s a label-free biosensor, combining printed electrodes and a microfluidic platform, able to quantify (≤ng/mL) in real time the immune response to vaccines or infection in a single device from a blood drop. Currently, a prototype(biosensor and a reader) is being validated with human healthy samples in order to assess its specificity and sensitivity.
Describe how your innovation model is distinct from any other organization in your field?
There's no equivalent device avalable in the market or under research so far. .
Several stakeholders will benefit from the BEAM project:
Patients, it will perceive an increased protection from novel vaccines as well as better perception of individualized follow-up with special focus on children.
Healthcare systems, the expenditure incurred due to massive vaccination programs could be rationally reduced and the surveillance of the public health will be improves to finally reach an evidence based rational use of economic health resources.
Healthcare professional, BEAM l will contribute to the patient follow up and the decision making on vaccine preventable diseases
Health industry viewpoint, BEAM will facilitate the assessment of marketed vaccines and those which under research.
What type of operating environment and internal organizational factors make your innovation successful?
The project BEAM is under progress so all the required actors are already together to deliver the platform. Two research centers (Leitat and Fraunhofer) together with two companies are actively working on tihis project. Leitat has being recognized as innovation center by several national and international institutions and it holds in-house expertise and knowlledge to push this project forward as done before in several national and international (e.g.FP7 projects).
How do you make sure you constantly innovate in light of (potential) external challenges, or your growth plan?
Taking into account information from: 1)Available project results 2)Evaluation of possible industrial outcome for the research “products” developed 3) Estimation of the economic impact of the processes developed under the project 4) Observation of market trends and positioning of the new product resulting from the project 5)Market analysis (actual market needs and size, EU/US and GAVI countries, 6) Identification of potential pharmaceutical/diagnostic companies .Additionally, specific actions to define the supply chain, key resources, customer segments, key activities and key partners required will also be done in order to develop a potential business model based on the biosensor platform.